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Anti-Infectives

Astellas is committed to developing treatments for serious, hard-to-treat infections

Despite stable or falling rates for many infections, every year in the EU infectious diseases cause tens of thousands of deaths, many millions of lost working days, and untold pain and suffering.1

True to our commitment to focus on areas of greatest unmet medical need, the Astellas Anti-Infectives portfolio includes medicines for invasive fungal infections and Clostridium difficile infection (CDI).

CDI is potentially fatal, with symptoms ranging from watery diarrhoea to severe, life-threatening intestinal complications.2 In one in ten patients, CDI causes or contributes to intensive care admission or death, or leads to surgery to remove part of the bowel (colectomy).3 The infection is common. In the EU, more than six patients contract CDI per 10,000 bed days4 and it is estimated to cost the region three billion Euros per year.5

Astellas is committed to developing further treatments for serious, hard-to-treat infections; we are currently investigating several therapies for managing invasive fungal infections.

1.European Center for Disease Prevention and Control. Microbes without borders: Key facts on infectious diseases in Europe. 2007. Available at http://ecdpc.europa.eu/pdf/ECDC_2007_06_07_Epi_report
2. Bauer MP, Kuijper EJ, van Dissel JT. European Society of Clinical Microbiology and Infectious Diseases (ESCMID): treatment guidance document for Clostridium difficile infection (CDI). Clin Microbiol Infect 2009;15:1067–79.
3. Bauer MP, Noretmans DW, van Benthem BH, et al. Clostridium difficile infection in Europe: a hospital-based survey. Lancet 2011;377:63–73.
4. Davies KA, Longshaw CM, Davis GL, Ashe S, Ashwin H, Lee F, Wilcox M H. First report from European, multi‐centre, prospective bi‐annual point prevalence study of Clostridium difficile Infection in hospitalised patients with Diarrhoea (EUCLID). ECCMID 2013; Poster: LB-2968
5. European Centre for Disease Prevention. Clostridium difficile infection – basic facts. Available at www.ecdc.europa.eu/EN/HEALTHTOPICS/CLOSTRIDIU Last accessed 12 February 2013.

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APEL/16/0024/APEL January 2017